PYRIMIDINE-SPECIFIC ANTIBODIES WHICH REACT WITH DEOXYRIBONUCLEIC ACID (DNA)
نویسندگان
چکیده
منابع مشابه
Pyrimidine-specific Antibodies Which React with Deoxyribonucleic Acid (dna).
Progress in a program to synthesize antigens which might be used to elicit antibodies specific for nucleic acid components has been reported.1 In the foregoing paper, the properties and biochemical applications of an antiserum complementary to purin-6-oyl residues were outlined. It was demonstrated, using the complementfixation reaction, that this "anti-purinoyl" antibody cross-reacted with den...
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Substances that have the properties of antibodies and react with DNA from various sources are frequently found in the sera of patients with systemic lupus erythematosus." 2 They appear to be formed spontaneously, perhaps as autoantibodies, but the stimulus for their production is not known. There have been many attempts to induce the formation of antibodies with specificity towards DNA,3-5 but ...
متن کاملAntibodies which react with nucleic acids.
During the past 5 years, several procedures for inducing antibodies capable of reacting with nucleic acids have been developed. These include immunization with phage lysates, ribosomes, purines, and pyrimidines or derivatives thereof coupled to proteins and polypeptides, denatured DNA or oligodeoxynucleotides complexed with methylated bovine serum albumin, and Gram-negative bacteria. It is now ...
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In continuation of studies on antibodies which react with informational macromolecules,1 the experimental induction with hapten-conjugated proteins2-5 of antisera capable of RNA cross-reaction has been attempted with several novel conjugates. These immunogens comprise 2,4-quinazolinedione-6-azo-, pseudouridine-, and dihydrouridine-albumins. Ancillary antigens containing uridine substituents6 we...
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* This work was supported by grant 23571 of the National Science Foundation, and grant AI04865-02 from the National Institutes of Health. Mortenson, L. E., Ann. Rev. Microbiol., 17, 115 (1963). 2 Mortenson, L. E., Biochim. Biophys. Acta, 81, 473 (1964). 3 Wilson, P. W., in Handbuch der P;flanzenphysiologie, ed. W. Ruhland (Berlin: Springer, 1958), vol. 8, p. 9. 4 McNary, J. E., and R. H. Burris...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1963
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.49.5.662